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KMID : 0812020170230030341
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Korean Journal of Neurogastroenterology and Motility
2017 Volume.23 No. 3 p.341 ~ p.348
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Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
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Fabisiak Adam
Wwodarczyk Jakub
Fabisiak Natalia
Storr Martin
Fichna Jakub
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Abstract
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Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.
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KEYWORD
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Ebastine, Irritable bowel syndrome, Mast cells, Receptors, histamine
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